Research Domains

Wound Healing and Regeneration

Our cerebral line of research deals with elucidation of molecular and cellular mechanisms of appendage regeneration in the lizard Hemidactylus flaviviridis. Role of numerous signalling pathways, which are conserved in humans, has been identified in initiation and progression of epimorphic regeneration in lizard as well as in teleost fish.  We have recognised key proteins involved in regeneration of various tissues including nerves, muscle, cartilage and skin. The lab has generated the first transcriptome-wide sequence data in the lizard and reported known and putative signalling molecules.

Embryonic Development

Our lab uses domestic chicken model, Gallus gallus to study the genetic, reproduction and developmental toxicity of pesticides that are regularly utilized in agriculture. Embryonic developmental pathways altered due to pesticide exposure have been recognized and correlated with birth defects often seen in exposed humans. A two-generation study has also yielded insights into the persistent effects across generations.

In-vitro toxicity studies

We have collaborated with the Department of Chemistry at the University to develop nature-identical compounds showing candidacy for cancer therapeutics.

Organogenesis and Disease Pathology

Our research interest stays in understanding the key genes and proteins associated with the developmental pathways in zebrafish. We target major developmental stages using chemical inhibitors to comprehend the signifance of affected molecules.